To me this quote means that when we know we have a limit, it bothers us, and we are never satisfied until we exceed or break free from our restraints. When one thinks of something in restraint, a bird in a cage comes to mind. The birds frantically hops around trying to spread it's wings as much as it can, but in doing this creates unease, and makes itself worn out and tired. Thus we are much like birds in a cage, and until we, or a bird are let free, we will all remain uneasily, because it is part of our makeup to be free without restraint, much like a wild animal.
Kay Redfield Jamison, An Unquiet Mind, Alfred A. Knopf, INC. 1995, page 109
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